hek293 cells — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T60003	AC1-IN-1		Adenylyl cyclase
	AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM).		Adenylyl cyclase
T11211	EP4 receptor antagonist 1		Prostaglandin Receptor
	EP4 Receptor Antagonist 1 is a highly potent and selective competitive prostanoid EP4 receptor antagonist, effective for cancer immunotherapy. It inhibits both human and mouse EP4 receptors with IC50 values of 6.1 nM and...		Prostaglandin Receptor
T4378	MS049		Histone Methyltransferase
	MS 049 is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC 50 of 34 nM and 43 nM, respectively.		Histone Methyltransferase
T3174	Taprenepag	CP-544326	Prostaglandin Receptor
	Taprenepag (CP-544326) (CP-544326) is a potent and selective prostaglandin E2 receptor agonist (EC50 = 2.8 nM). Taprenepag has been used in trials studying the treatment of Ocular Hypertension and Glaucoma, Open-Angle.		Prostaglandin Receptor
T8851	I3MT-3	HMPSNE	Hippo pathway
	I3MT-3 (HMPSNE) (HMPSNE) is a potent, selective and cell membrane permeability inhibitor of 3-mercaptopyruvate sulfur transferase (3MST), which targets the persulfated cysteine residues located at the active site of 3MST...		Hippo pathway
T17258	WRG-28		Discoidin Domain Receptor (DDR)
	WRG-28 is a potent and selective, allosteric discoidin domain receptor 2 (ddr2) inhibitor(IC50 : 230 nM)		Discoidin Domain Receptor (DDR)
T2694	KN-62		CaMK , P2X Receptor , Autophagy
	KN-62 is a potent and specific Ca2+/calmodulin-dependent protein kinase II (CaMKII) inhibitor with Ki of 0.9 μM.		CaMK , P2X Receptor , Autophagy
T7155	JH-II-127		LRRK2
	JH-II-127 is an orally inhibitor of leucine-rich repeat kinase 2 (LRRK2). It inhibits WT LRRK2, G2019S LRRK2 and A2016T LRRK2 (IC50s = 6.6, 2.2, and 47.7 nM, respectively),		LRRK2
T9240	Sulfopin	Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-	Others
	Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.		Others
T9564	IRE1α kinase-IN-1		IRE1
	IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph...		IRE1
T19840	GSK-F1	PI4KA inhibitor-F1	PI4K
	GSK-F1 (PI4KA inhibitor-F1) is a novel potent PI4KA inhibitor.		PI4K
T7196	HG-10-102-01		LRRK2
	HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2, IC50 of 20.3 nM).		LRRK2
T3673	Mollugin	Rubimaillin	HER , JAK
	Mollugin (Rubimaillin) may be a JAK2 inhibitor and inhibits LPS-induced inflammatory responses by blocking the activation of the JAK-STAT pathway. Mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upr...		HER , JAK
T14673	BMS 299897		Beta Amyloid , Gamma-secretase
	BMS 299897 is a sulfonamide γ-secretase inhibitor. It has an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).		Beta Amyloid , Gamma-secretase
T1537	Rapamycin	Sirolimus,AY 22989,NSC-2260804	Others , Endogenous Metabolite , Antibiotic , mTOR , Autophagy , Antifungal
	Rapamycin (AY 22989) is a natural product of macrolides, an mTOR inhibitor with specificity (HEK293 cells: IC50=0.1 nM). Rapamycin has immunosuppressive activity and induces autophagy.
T11720	JNJ-18038683		5-HT Receptor
	JNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively.		5-HT Receptor
T19122	3-Methylvaleric Acid		Others , Endogenous Metabolite
	3-Methylvaleric Acid is an edible grade flavor present in tobacco.3-Methylvaleric Acid enhances intracellular cAMP accumulation and CRE-luciferase activity in CHO-K1 cells and HEK293 cells.		Others , Endogenous Metabolite
T1842	XMD17-109	XMD17 109,ERK5-IN-1	ERK
	XMD17-109 (ERK5-IN-1) is a new selective ERK-5 inhibitor (EC50: 4.2 uM, HEK293 cells).		ERK
T12323	ORM-15341		Androgen Receptor
	ORM-15341 is a potent and full antagonist for human AR (hAR)( with IC50 values of 38 nM as shown by transactivation assays in AR-HEK293 cells)		Androgen Receptor
T15677	KY1220		Wnt/beta-catenin
	KY1220 destabilizes both β-catenin and Ras by targeting the Wnt/β-catenin pathway. It has an IC50 of 2.1 μM in HEK293 reporter cells.		Wnt/beta-catenin